RNA Nanoparticles Derived from Three-Way Junction of Phi29 Motor pRNA Are Resistant to I-125 and Cs-131 Radiation
نویسندگان
چکیده
منابع مشابه
Addition to Entropy-Driven One-Step Formation of Phi29 pRNA 3WJ from Three RNA Fragments
Page 2221. This sentence should have appeared at the end of the abstract: Here entropy-driven is referring to a dominating entropic contribution to the increased stability of the 3WJ 2′‑F and 3WJ RNA compared to the 3WJ DNA , instead of referring to the absolute role or total energy governing 3WJ folding.
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The bacteriophage phi29 DNA packaging motor, one of the strongest biological motors characterized to date, is geared by a packaging RNA (pRNA) ring. When assembled from three RNA fragments, its three-way junction (3WJ) motif is highly thermostable, is resistant to 8 M urea, and remains associated at extremely low concentrations in vitro and in vivo. To elucidate the structural basis for its unu...
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ژورنال
عنوان ژورنال: Nucleic Acid Therapeutics
سال: 2015
ISSN: 2159-3337,2159-3345
DOI: 10.1089/nat.2014.0525